CJC-1295 NO DAC (Mod GRF 1-29) (5mg)
$40.00 $21.00
CJC-1295 NO DAC (MOD GRF 1-29) Product Information
Our CJC-1295 NO DAC (MOD GRF 1-29) is a high-purity, synthetic peptide available in a 5mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU is P-MODGRF129.
Pricing and Discounts:
5-8 units: A 5% discount is applied, with a price of $38.95 per unit.
9+ units: A 10% discount is applied, with a price of $36.90 per unit.
We also offer FREE shipping on all orders over $200.
CJC-1295 Peptide (No DAC): A Focus on Growth Hormone Pulsatility 🔬
What is CJC-1295 (No DAC)?
CJC-1295 (No DAC), also known as Modified GRF (1-29), is a synthetic peptide based on the first 29 amino acids of the natural Growth Hormone-Releasing Hormone (GHRH). It is modified with four amino acid substitutions that are thought to increase its stability and resistance to degradation. Unlike its counterpart with a Drug Affinity Complex (DAC), this version has a shorter half-life, which makes it an interesting subject for research into natural, pulsatile growth hormone (GH) release.
Key Areas of Scientific Research 🧪
1. Mechanism of Action
CJC-1295 (No DAC) is thought to act on the GHRH receptor on pituitary cells. This interaction may activate a signaling cascade involving G-proteins and secondary messengers like cAMP and IP3. This process is believed to lead to the transcription of genes related to GH synthesis and the subsequent release of GH from the pituitary gland.
2. GH Pulsatility
Research suggests that CJC-1295 (No DAC) may significantly modulate the GH-IGF-1 axis. One study on a partially modified version of GRF 1-29 found an apparent 70-107% increase in the mean 12-hour release of GH and a 28% increase in IGF-1 (Insulin-like Growth Factor 1). This increase was associated with a significant gain in muscle tissue and a potential increase in skin tissue thickness. These findings suggest a potential role for the peptide in promoting muscle hypertrophy and skin cell proliferation.
3. Ancillary Research
Intestinal Studies: Research in experimental models suggests a potential interaction between GHRH analogs like CJC-1295 (No DAC) and receptors in the gastrointestinal system, which might influence bowel movement.
Heart Rate: Preliminary research in murine models suggests that Modified GRF 1-29 may have the potential to improve heart rate and the heart's ability to pump blood, particularly following a heart attack.
4. Peptide Combinations
CJC-1295 (No DAC) is often studied in combination with other short-acting peptides. When combined with Growth Hormone Secretagogues (GHSs) like Ipamorelin, which act on the ghrelin receptors in the same pituitary cells, researchers suggest a potential for synergistic action, leading to an even greater elevation of GH secretion.
Product Specifications 📊
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.9 g/mol
Other Known Titles: CJC-1295 Without DAC, Modified GRF (1-29)
Important Notice: CJC-1295 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.