Decapeptide-12 (200mg)
$160.00 $140.00
Decapeptide-12 Product Information
Our Decapeptide-12 is a high-purity, synthetic peptide available in a 200mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU is P-Decapeptide-12.
Pricing and Discounts:
5-8 units: A 5% discount is applied, with a price of $228.00 per unit.
9+ units: A 10% discount is applied, with a price of $216.00 per unit.
We also offer FREE shipping on all orders over $200.
Decapeptide-12: A Focus on Skin Pigmentation and Cellular Regulation 🔬
What is Decapeptide-12?
Decapeptide-12 is a synthetic, 10-amino-acid peptide that does not mimic any naturally occurring peptide. It was designed to potentially inhibit melanin production in the skin by suppressing the activity of the enzyme tyrosinase, which is crucial for melanin synthesis. Its primary research application is in reducing hyperpigmentation and addressing various skin conditions.
Key Areas of Scientific Research 🧪
1. Melasma and Hyperpigmentation
The main body of research on Decapeptide-12 focuses on its potential to reduce melasma, solar lentigines, and post-inflammatory hyperpigmentation (PIH).
Melasma: Clinical studies on subjects with melasma have shown visible reductions in its appearance. One study reported a complete clearance of melasma in 25% of subjects after six weeks.
Solar Lentigines: In a study on solar lentigines (hyperpigmentation from sun damage), 38.5% of subjects reportedly achieved complete clearance, and all subjects showed some improvement.
Post-inflammatory Hyperpigmentation: A clinical case study on pigmented skin suggested that Decapeptide-12 might accelerate the clearance of PIH compared to a placebo.
2. Mechanism of Action
Decapeptide-12 is posited to work by inhibiting the enzyme tyrosinase. Tyrosinase catalyzes the first two steps of melanogenesis (melanin synthesis): the hydroxylation of tyrosine to DOPA and the oxidation of DOPA to DOPAquinone. By potentially binding to tyrosinase, Decapeptide-12 may block these reactions, thereby reducing the production of melanin pigments.
3. Cell Aging
Studies have explored the potential of Decapeptide-12 to influence cellular aging. One study measured its impact on sirtuin genes, a family of genes believed to be involved in cellular metabolism and stress resistance. The results suggested that Decapeptide-12 might increase the transcription of several sirtuin genes, including:
SIRT1: Increased by 141 ± 11%, which may enhance cellular resilience and delay aging.
SIRT3: Increased by 121 ± 13%, potentially improving mitochondrial function and energy metabolism.
SIRT6: Increased by 147 ± 8%, possibly contributing to improved genomic stability and DNA repair.
SIRT7: Increased by 95 ± 14%, which may influence nucleolar functions and cellular homeostasis.
Product Specifications 📊
Molecular Formula: C65H90N18O17
Molecular Weight: 1311.46 g/mol
Important Notice: Decapeptide-12 is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.