Fragment 176-191 (5mg / 10mg)
$84.00 - $52.00
Fragment 176-191 Product Information
Our Fragment 176-191 is a high-purity, synthetic peptide available in 5mg and 10mg sizes. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU is P-FRAG176-191.
Pricing and Discounts:
5-8 units: A 5% discount is applied, with a price range of $41.80 - $68.40.
9+ units: A 10% discount is applied, with a price range of $39.60 - $64.80.
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The user wants to know about the peptide Fragment 176-191, also known as hGH Fragment 176-191 or Lipolytic Fragment. The provided text covers its overview, chemical makeup, and research into its potential effects on fat cells, cartilage regeneration, and hyperglycemia.
Fragment 176-191: An Overview
Fragment 176-191 is a synthetic peptide derived from the human growth hormone (hGH) molecule. It is a fragment of the parent hormone, specifically composed of amino acids 176 through 191. Researchers are primarily interested in its potential to influence weight loss and fat burning without causing the hyperglycemia often associated with full hGH. It also contains a disulfide bridge between two cysteine amino acids, which may increase its stability and resistance to degradation.
Key Research Areas 🔬
1. Fat Cells and Weight Loss
Fragment 176-191 is a popular subject of research for its potential lipolytic (fat-burning) properties.
Mechanism of Action: The peptide is posited to influence fat burning through multiple mechanisms. It may upregulate the expression of beta-3 adrenergic receptors in fat cells, potentially increasing the cells' sensitivity to lipolytic signals. However, studies on mice with disabled lipolytic receptors still showed weight loss, suggesting other mechanisms may be at play, such as increased energy expenditure and fat oxidation.
Clinical Trial: A 12-week clinical trial involving 300 subjects suggested that one group exposed to the peptide experienced an apparent decrease in body weight, potentially by around 5.7 pounds.
2. Cartilage Regeneration
Some research suggests that Fragment 176-191 may also have regenerative properties. A study on knee osteoarthritis in experimental models found that the peptide, particularly in combination with hyaluronic acid, appeared to contribute to cartilage regeneration and reduce lameness. The combined treatment was shown to be more effective than either treatment alone.
3. Hyperglycemia
Unlike full hGH, which can cause hyperglycemia, Fragment 176-191 has been studied for its potential effects on blood glucose. Research suggests that it may slightly increase levels of blood glucose and lactate while reducing the activity of glycogen synthase enzymes, which are involved in converting glucose to glycogen for storage.
Product Specifications 📊
Molecular Formula: C78H125N23O23S2
Molecular Weight: 1817.12 g/mol
Other Known Titles: hGH Fragment 176-191, Lipolytic fragment
Important Notice: Fragment 176-191 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.