Hexarelin (5mg)

Hexarelin, also known as Examorelin, is a synthetic growth hormone-releasing peptide (GHRP) containing six amino acids. It is being investigated for its potential to stimulate the release of growth hormone (GH) by mimicking the action of the natural hormone ghrelin. This is believed to occur through the activation of growth hormone secretagogue receptors (GHS-Rs), particularly in the pituitary gland and hypothalamus. Research also suggests Hexarelin may have effects on appetite and cardiovascular function.

Product Information

Pricing

Chemical Makeup

Research and Clinical Studies

Growth Hormone Release

Studies have investigated Hexarelin's potential to stimulate GH release in different age groups. In a study, Hexarelin appeared to induce higher GH levels than GHRH alone in adolescent and mature models. While it also appeared to increase GH in elderly and adolescent models, its effects were reportedly less pronounced compared to a GHRH and arginine combination in the elderly group (8). It is important to note that Hexarelin has also been posited to cause a transient receptor desensitization that may last for days or weeks (5).

Research also suggests that Hexarelin and GHRH may have a synergistic effect on GH synthesis due to their distinct pathways. A study on GH1 murine tumor cells, which are insensitive to GHRH, reported that Hexarelin appeared to induce GH release, and when presented with GHRH, the effects were additive (9).

Cardiovascular Activity

Research has suggested that Hexarelin may have potential positive effects on the cardiovascular system. An acute administration of the peptide was reported to increase left ventricular ejection fraction (LVEF) without a significant change in blood pressure. In models with disrupted coronary artery flow, Hexarelin appeared to increase cardiac output and arterial pressure (10). Furthermore, in models with myocardial infarction, daily exposure to Hexarelin reportedly increased stroke volume and cardiac output while decreasing peripheral resistance (12).

Body Composition & Muscle Tissue

A study aimed at determining the effects of Hexarelin on body composition suggested that the peptide's ability to stimulate GH release is negatively correlated with fat mass. Increased fat mass may lead to a reduction in GH release following Hexarelin exposure, while gender reportedly showed no significant impact (13).

Preliminary experiments also suggest that Hexarelin may have muscle-sparing effects in models exposed to catabolic conditions. Studies have reported an apparent reduction in the loss of muscle mass and strength, indicating that the peptide may help attenuate muscle degradation (14, 15).

Disclaimer: Hexarelin peptide is available for research and laboratory purposes only.