Ipamorelin (5mg)

Ipamorelin is a synthetic pentapeptide that acts as a Growth Hormone Secretagogue (GHS). It's designed to activate ghrelin receptors (GHS-Rs) on the pituitary gland, which may then stimulate the release of growth hormone (GH). Research suggests that Ipamorelin is highly selective and may potentially increase GH production without significantly affecting other pituitary hormones like prolactin or ACTH. This makes it a potential candidate for research into anabolic actions, as increased GH levels may lead to higher production of insulin-like growth factor-1 (IGF-1).

Product Information

Pricing

Chemical Makeup

Research and Clinical Studies

Selective Agonism & Growth Hormone Synthesis

Ipamorelin is being investigated for its selective agonism of GHS-Rs. Studies suggest it may stimulate the release of GH from pituitary cells without significantly impacting the levels of other hormones like prolactin or ACTH (1, 2). The proposed mechanism involves the activation of intracellular signaling pathways that lead to an increase in intracellular calcium and the activation of protein kinase C (PKC), which together may promote the release of GH from pituitary cells (3). A clinical trial reported that Ipamorelin appeared to boost GH levels by over 60 times compared to a placebo (4).

Bone & Muscle Tissue

Research suggests that Ipamorelin may influence bone mineral density. The peptide is thought to stimulate osteoblasts (bone-forming cells) via GH-mediated mechanisms, potentially leading to increased proliferation and growth. A study on murine models reported that Ipamorelin may contribute to increased bone mineral content (BMC) and an enlargement in the cross-sectional area of the bones, without affecting volumetric bone mineral density (5).

Additionally, Ipamorelin may mediate anabolic actions. Studies have explored its impact on nitrogen balance, which is a key indicator of anabolic state. In one investigation, Ipamorelin appeared to reduce the expression of liver urea cycle enzymes and help restore nitrogen balance in catabolic conditions (8).

Digestion & Appetite

Ipamorelin has also been researched for its potential effects on the digestive system and appetite. A study reported that Ipamorelin appeared to accelerate the process of gastric emptying in murine models with a surgically decelerated process. This observation led researchers to hypothesize that the peptide may enhance the contractility of gastric smooth muscles (6).

The potential actions of Ipamorelin on ghrelin receptors may also lead to an enhancement of hunger signals and an increase in body mass. Research suggests that models exposed to Ipamorelin may sustain a surge in body weight and a proportional increase in fat pads. It's speculated that this effect on body composition may be a GH-independent mechanism linked to increased feeding (7).

Disclaimer: Ipamorelin peptide is available for research and laboratory purposes only.