MOTS-C (10mg)
$109.00 $96.00
MOTS-C Product Information
Our MOTS-C is a high-purity, synthetic peptide available in a 10mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU is P-MOTS-C-10mg.
Pricing and Discounts
5-8 units: A 5% discount is applied, with a price of $110.20 per unit.
9+ units: A 10% discount is applied, with a price of $104.40 per unit.
We also offer FREE shipping on all orders over $200.
MOTS-c (mitochondrial open-reading-frame of the 12S rRNA-c) is a novel mitochondria-derived peptide (MDP) that is being researched for its potential as a mitokine (mitochondrial hormone) to regulate cellular and systemic metabolism. It is composed of 16 amino acids and is believed to act by stimulating the AMPK pathway, a key regulator of metabolism. Its expression may decline with age, suggesting a possible role in age-related metabolic dysfunction.
Key Research Areas 🔬
1. Metabolic Regulation
Mechanism: MOTS-c is thought to activate the AMPK pathway, which may increase glucose uptake and improve insulin sensitivity. It may also translocate to the cellular nuclei to alter gene expression, particularly those with antioxidant response elements (ARE).
Studies:
Muscle Metabolism: Research suggests that MOTS-c may improve skeletal muscle metabolism by enhancing glucose uptake, which could counter age-related insulin resistance.
Fat Cell Metabolism: In a study on mice fed a high-fat diet, those exposed to MOTS-c were leaner and more energetic, suggesting the peptide may prevent fat accumulation and induce glucose uptake. It is hypothesized to act by affecting the folate-methionine cycle and promoting AMPK activation.
2. Tissue Health and Regeneration
Bone Health: MOTS-c is being researched for its potential to regulate the TGF-beta/SMAD pathway, which is crucial for bone formation. Studies suggest it may stimulate the expression of genes related to osteogenesis, potentially improving bone density and strength.
Cardiac Function: While not directly influencing the heart muscle, research suggests MOTS-c may improve the functioning of endothelial cells that line blood vessels, potentially affecting blood pressure and clotting.
Cell Lifespan: The peptide is being explored for its potential link to cellular longevity. Its function may be influenced by its amino acid composition, with researchers studying how specific residues might affect its activity and influence the aging process.
Product Specifications 📊
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.64 g/mol
Other Titles: Mitochondrial-derived peptide MOTS-c, Mitochondrial open reading frame of the 12S rRNA-c
Important Notice: MOTS-c peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.