NAD+ (100mg / 750mg)
$17.00 - $115.00
NAD+ Product Information
Our NAD+ is a high-purity product available in two sizes: 100mg and 750mg. Provided in a lyophilized powder form with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-NADPLUS-100-750.
NAD+ (Nicotinamide Adenine Dinucleotide) is an endogenous nucleotide and coenzyme that is being researched for its potential role in regulating key cellular processes such as metabolism, energy production, and DNA repair. It is considered to be a key component in more than 500 enzymatic reactions. Its levels are thought to decline with age, and researchers are exploring the use of NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), to potentially boost its levels.
1. Mechanisms of Action 🧪
NAD+ is a coenzyme for three major classes of enzymes that are being studied for their potential roles in cellular function:
Sirtuins (SIRTs): These are deacetylase enzymes that are thought to be involved in mitochondrial health and stem cell regeneration. Research suggests that NAD+ may be crucial for SIRT activity, and a deficiency could lead to reduced energy production and other functional limitations.
Poly ADP Ribose Polymerase (PARPs): These enzymes are believed to be essential for genomic stability and DNA repair. Research suggests that PARPs may use NAD+ to initiate DNA repair mechanisms after damage, highlighting NAD+'s crucial role in maintaining genomic integrity.
Cyclic ADP Ribose Synthetase (cADPRS): These enzymes are involved in stem cell regeneration and DNA repair and are thought to be dependent on NAD+ for their function.
2. Research and Clinical Studies 🔬
Neurodegenerative and Age-Related Conditions
Neuroprotection: A study on aged mice suggested that NMN, an NAD+ intermediate, may help restore mitochondrial function in nerve and brain cells. In a study on a rat neuronal culture, direct replenishment of NAD+ appeared to significantly improve DNA repair and cell viability after ischemic stress.
Productive Aging: Research on aging mice suggested that NMN may promote NAD+ synthesis, which correlated with potential improvements in energy metabolism, physical activity, and lipid profiles.
Kidney Health: Studies suggested that NAD+ supplementation in aged mice kidney cells may promote SIRT activity, which appeared to offer neuroprotective potential against glucose-induced kidney cell hypertrophy.
Metabolism and Skeletal Function
Energy Production: Research suggests that NAD+ is vital for cellular respiration, acting as a key helper molecule in converting nutrients into energy. In aged mice, daily NMN exposure appeared to increase ATP production and improve mitochondrial function in skeletal muscle.
Liver Health: In mice models, increasing NAD+ levels appeared to show positive potential in preventing obesity and alcoholic hepatitis while possibly improving glucose homeostasis and overall liver function.
Cardiovascular Health
Cardioprotection: Research suggests that NAD+ deficiency may lead to reduced SIRT activity and a subsequent reduction in energy production. A study on mice suggested that NMN exposure prior to induced-ischemia may produce a cardioprotective function.
3. Product Information 🧬
Molecular Formula: C21H27N7O14P2
Molecular Weight: 663.43 g/mol
Other Known Titles: Nicotinamide adenine dinucleotide
Important Notice: NAD+ peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.