Pal-GHK (200mg)
$127.00 $106.00
Pal-GHK Product Information
Our Pal-GHK is a high-purity, synthetic peptide available in a 200mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-PAL-GHK.
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Palmitoyl-GHK (Pal-GHK) is a synthetic peptide that consists of the amino acid sequence Gly-His-Lys (GHK) attached to a palmitic acid molecule. The addition of the palmitoyl group is believed to enhance the peptide's ability to penetrate the skin's outer layer. Pal-GHK is being researched for its potential to stimulate collagen synthesis, reduce wrinkle depth, and act as an antioxidant. The GHK sequence is a naturally occurring fragment of collagen, which is thought to act as a signal to fibroblasts to initiate the production of new collagen.
1. Mechanisms of Action 🧪
Pal-GHK is hypothesized to exert its actions through several pathways:
Collagen Synthesis: The GHK sequence is believed to signal fibroblasts—the cells responsible for producing collagen and other extracellular matrix (ECM) components—to increase production.
Antioxidant Action: The peptide may neutralize various free radicals (such as hydroxyl, superoxide, and peroxyl radicals), which are unstable molecules that can cause cellular damage and contribute to aging.
Anti-inflammatory Potential: Pal-GHK may reduce inflammation by suppressing the activation of signaling pathways like NF-κB and p38 MAPK.
Protecting from Oxidative Stress: It is suggested that the peptide may increase the expression of Nrf2, a protein that regulates antioxidant proteins, and potentially inhibit lipid peroxidation.
2. Research and Clinical Studies 🔬
Skin Health and Aging
Collagen Production: A clinical study suggested that Pal-GHK may stimulate collagen synthesis, resulting in a statistically significant increase in skin thickness of about 4%.
Wrinkle Reduction: Clinical studies have investigated the peptide in cream form and reported an apparent reduction in wrinkle length, depth, and texture inconsistency.
Combination with Other Peptides: When combined with another palmitoylated peptide (Pal-GQPR), a clinical study reported an apparent reduction in wrinkle depth, volume, and density.
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Antioxidant and Anti-inflammatory Effects
Free Radical Scavenging: Laboratory experiments suggest that the GHK sequence may have potent antioxidative potential, even more powerful than some commonly used antioxidants.
Iron Release and Lipid Peroxidation: Pal-GHK is thought to potentially reduce the release of iron from damaged tissue, which in turn may lower the rate of lipid peroxidation.
Inflammatory Markers: In a study on a murine model of lung tissue damage, Pal-GHK appeared to suppress inflammatory signaling pathways, leading to reduced inflammatory cell infiltration and lower levels of inflammatory cytokines.
3. Product Information 🧬
Molecular Formula: C30H54N6O5
Molecular Weight: 578.8 g/mol
Other Known Titles: Palmitoyl Tripeptide-1, Palmitoyl oligopeptide, Biopeptide-CL
Important Notice: Pal-GHK peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.