PEG-MGF (5mg)
$46.00 $33.00
PEG-MGF Product Information
Our PEG-MGF is a high-purity, synthetic peptide available in a 5mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-PEGMGF-5.
Pricing and Discounts
5-8 units: A 5% discount is applied, with a price of $59.85 per unit.
9+ units: A 10% discount is applied, with a price of $56.70 per unit.
We also offer FREE shipping on all orders over $200.
Sources
PEG-MGF, or polyethylene glycol (PEG)-ylated MGF, is a synthetic form of Mechano Growth Factor (MGF). MGF, also known as IGF-1Ec, is a natural isoform of the insulin-like growth factor (IGF-1) family. The addition of a PEG molecule is believed to extend the peptide's short half-life, potentially making its action more durable and impactful in research settings. MGF is thought to be produced in response to muscle stress and injury.
1. Mechanisms of Action 🧪
PEG-MGF is hypothesized to function in several ways:
Cell Proliferation: MGF is believed to stimulate the proliferation of muscle stem cells and myoblasts, which are crucial for muscle repair and growth.
Inflammatory Modulation: In models of muscle injury, MGF appeared to reduce the expression of pro-inflammatory cytokines (such as TNF-α and IL-1β) and oxidative stress markers, suggesting a potential anti-inflammatory action.
Cellular Regeneration: Research suggests MGF may inhibit cell death (apoptosis) and enhance the migration of stem cells to injured tissues, a process crucial for repair and regeneration.
Gene Expression: It may play a role in regulating gene expression related to muscle repair and growth, though direct effects on certain satellite cell markers like MyoD and myogenin were not definitively established in all studies.
Licensed by Google
2. Research and Clinical Studies 🔬
Muscle and Tissue Repair
Muscle Hypertrophy: In a study on muscle cell cultures, MGF appeared to enhance cell proliferation and fusion, leading to increased myotube size, particularly in younger cells. In older cells, it seemed to induce muscle hypertrophy while reducing the number of reserve cells, suggesting it may encourage these cells to participate in muscle formation.
Bone Fracture Healing: A study on rabbits with bone defects suggested that MGF might enhance the healing process, possibly by influencing the cell cycle and activating the MAPK-Erk1/2 signaling pathway, a mechanism that promotes cell proliferation.
Neuroprotection and Cardioprotection
Neuroprotection: Studies on mice bred to overproduce MGF in the hippocampus showed elevated levels of BrdU, a marker of cell proliferation, and enhanced neurogenesis.
Cardioprotection: In a study on rats with induced hypoxia (low oxygen), MGF appeared to increase the migration of stem cells to the heart, potentially inhibiting programmed cell death (apoptosis) and supporting tissue regeneration.
3. Product Information 🧬
Molecular Formula: C121H200N42O39
Molecular Weight: N/A
Other Known Titles: PEG-MGF-E, PEG-MGF-Ct24E
Important Notice: PEG-MGF peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.