Pinealon (20mg)
$56.00 $35.00
Pinealon Product Information
Our Pinealon is a high-purity, synthetic peptide available in a 20mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-PINEALON-20.
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Pinealon is a synthetic tripeptide (Glu-Asp-Arg) that is being researched for its potential impact on the central nervous system, with a focus on its proposed neuroprotective, anti-aging, and neuroregulatory properties. It's theorized to be able to cross the blood-brain barrier and cellular membranes to interact with DNA and modulate cellular pathways.
1. Mechanisms of Action 🧪
Pinealon's potential actions are hypothesized to involve several key cellular and molecular pathways:
Antioxidant and Anti-apoptotic Potential: At lower concentrations, the peptide may restrict the synthesis of reactive oxygen species (ROS), which are linked to cellular stress. This may reduce the activation of the MAPK / ERK signaling pathways, which are associated with cellular apoptosis and inflammation. Pinealon also appears to modulate the levels of the caspase-3 enzyme, an initiator of cell death.
DNA Interaction and Gene Expression: Pinealon is suggested to be able to interact directly with DNA molecules. This may lead to an increase in the synthesis of the 5-tryptophan hydroxylase enzyme, which is critical for serotonin production. Studies suggest this potential is due to Pinealon binding to a specific DNA sequence in the gene's promoter region.
Modulation of Cellular Processes: At higher concentrations, the peptide may modulate the cell cycle. In muscle cells, it is suggested to increase the levels of irisin, a hormone linked to fat burning and telomere elongation, potentially counteracting cellular aging.
2. Research and Clinical Studies 🔬
Neuroprotection and Brain Function
Neuroprotection: Studies on murine models of ischemic stroke suggested that Pinealon may help restore neurogenic processes and reduce neuroinflammation by modulating inflammatory markers like interleukin-6 and tumor necrosis factor.
Cognitive Function: In a study on offspring of female rats with prenatal hyperhomocysteinemia, Pinealon did not reduce the homocysteine levels but appeared to reduce the compound's toxic action, with the offspring exhibiting increased cognitive processing.
Serotonin Expression: Research on isolated brain cell cultures indicated that Pinealon may stimulate serotonin synthesis, with one study reporting a 1.9 times greater synthesis in younger cell cultures.
Aging and Metabolism
Cellular Anabolism: A clinical study on models with organic brain syndrome suggested that Pinealon exhibited anabolic potential, with researchers reporting an improvement in the functioning of the central nervous system and other vital organs.
Anti-Aging Potential: By potentially increasing irisin levels, Pinealon may protect DNA telomeres, which are believed to be linked to cellular aging.
3. Product Information 🧬
Molecular Formula: C15H26N6O8
Molecular Weight: 418.4 g/mol
Other Known Titles: EDR, Glu-Asp-Arg
Important Notice: Pinealon peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.