PT-141 (Bremelanotide) (10mg)
$41.00 $23.00
PT-141 (Bremelanotide) Product Information
Our PT-141 (Bremelanotide) is a high-purity, synthetic peptide available in a 10mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-PT141-10.
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PT-141, also known as Bremelanotide, is a synthetic cyclic peptide. It is a derivative of the hormone alpha-MSH and acts as an agonist for melanocortin receptors, specifically MC3R and MC4R, which are located in the central nervous system. Its primary area of research is in evaluating its potential to influence sexual function and arousal.
1. Mechanisms of Action 🧪
PT-141 is hypothesized to work through the following pathways:
Melanocortin Receptor Activation: The peptide binds to and activates melanocortin receptors MC3R and MC4R. This activation is believed to stimulate neurons in the hypothalamus and other brain regions associated with sexual behavior.
Central Nervous System (CNS) Activation: Unlike other compounds that may act directly on the vasculature to produce an effect, PT-141's potential actions appear to originate in the CNS. The activation of hypothalamic neurons may lead to increased immunoreactivity and ultimately a state of sexual arousal.
Vasodilator Production: In penile tissues, the activation of MC4R is also posited to upregulate the production of nitric oxide (NO), a vasodilator. This may lead to improved erection potential, as research suggests the effect is mediated by the NO-cyclic GMP-dependent pathway.
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2. Research and Clinical Studies 🔬
Sexual Function and Arousal
Appetitive vs. Consummatory Behavior: Initial studies on female murine models suggested that PT-141 may selectively enhance appetitive sexual behaviors (like solicitation and desire) without impacting consummatory behaviors (like sexual pace or lordosis).
Brain Processing: A study using functional neuroimaging suggested that PT-141 may amplify brain activity in areas associated with sexual desire when exposed to erotic stimuli. It was also hypothesized to increase the functional connectivity between the amygdala and the insula, which are involved in emotional processing and interoception.
Penile Tissues: Studies indicate that PT-141 may increase cavernosal pressure, a key indicator of erectile function. This effect is thought to be mediated through a neuronal release of nitric oxide.
Other Potential Research Areas
Metabolic Processes: Due to the location and known function of the MC3R receptor in the hypothalamus, PT-141 is also being researched for its potential role in regulating energy homeostasis, appetite, and glucose and lipid metabolism.
3. Product Information 🧬
Molecular Formula: C50H68N14O10
Molecular Weight: 1025.18 g/mol
Other Known Titles: Bremelanotide
Important Notice: PT-141 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.