Receptor Grade IGF-1 LR3 (100mcg)
$25.00 $18.00
Receptor Grade IGF-1 LR3 Product Information
Our Receptor Grade IGF-1 LR3 is a high-purity, synthetic peptide available in a 100mcg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-IGF1LR3-100.
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Receptor Grade IGF-1 LR3 is a synthetic, high-purity variant of naturally occurring Insulin-like Growth Factor-1 (IGF-1). It has been structurally modified to have an extended 13-amino-acid N-terminal and a replacement of glutamic acid with arginine at residue 3. This alteration is believed to give it an increased anabolic potential and a reduced binding affinity to IGF-1 binding proteins (IGF-1BPs), which may allow it to act more freely in the body.
1. Mechanisms of Action 🧪
The potential actions of Receptor Grade IGF-1 LR3 are primarily focused on regulating cell growth and development.
Anabolic Effects: The peptide is suggested to have a greater anabolic potential than IGF-1, promoting weight gain, increasing organ weights, and improving the efficiency of feed use. In animal models, it appeared to reduce markers of muscle protein breakdown more effectively than IGF-1.
Insulin Receptor Sensitivity: IGF-1 LR3 is thought to improve insulin sensitivity and glucose metabolism. Research suggests it may stimulate glucose uptake through both IGF-1 receptors and other independent pathways.
Inhibiting Myostatin: Studies suggest that IGF-1 LR3 may reverse the adverse effects of myostatin, a protein that inhibits cellular differentiation. By mitigating myostatin's action, the peptide may help to increase lean muscle mass and reduce fat cell storage.
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2. Research and Clinical Studies 🔬
Cell Growth and Longevity
Growth Deficiency: In models of IGF-1 deficiency, IGF-1 LR3 and its analogs appeared to increase total length and growth, suggesting a potential in mitigating growth deficiencies.
Cell Lifespan: Preliminary studies on murine models suggest that IGF-1 LR3 may indirectly help to extend the lifespan of functional cells by mitigating common markers of physiological decline like muscle tears and neurological deficiencies.
Tissue Distribution
Reduced Binding: Research indicates that IGF-1 LR3 appears to bind less to binding proteins than endogenous IGF-1, which may lead to a faster clearance from the serum and a more even distribution into tissue.
Unique Localization: A study showed a distinct localization of IGF-1 LR3 in tissues such as the kidneys, ovaries, and adrenal glands, which are primarily involved in metabolic and reproductive functions.
3. Product Information 🧬
Molecular Formula: C400H625N111O115S9
Molecular Weight: 9117.5 g/mol
Other Known Titles: Long-(arg3) insulin-like growth factor-I, Insulin-like growth factor long chain R3
Important Notice: Receptor Grade IGF-1 LR3 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.