Selank (10mg)
$35.00 $22.00
Selank Product Information
Our Selank is a high-purity, synthetic peptide available in a 10mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-SELANK-10.
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Selank is a short, synthetic heptapeptide derived from the natural peptide Tuftsin. It is being researched for its potential neuro-modulating effects, which are hypothesized to stem from its influence on key systems in the central nervous system, including BDNF, serotonin, and GABA. The inclusion of a Pro-Gly-Pro (PGP) sequence in its structure may enhance its ability to cross the blood-brain barrier.
1. Mechanisms of Action 🧪
Selank's potential actions are believed to be multifaceted, involving several interconnected systems:
BDNF Regulation: Selank may influence the expression of Brain-Derived Neurotrophic Factor (BDNF), a protein critical for neuronal survival and growth. Research suggests it may increase BDNF mRNA levels, particularly in the hippocampus.
Neurotransmitter Modulation: It is thought to act on the serotonin and GABA (gamma-aminobutyric acid) systems. Selank may facilitate serotonin metabolism and appears to modulate the GABAergic system, which is involved in reducing neuronal excitability and anxiety.
Enkephalin Signaling: Selank may inhibit the enzymes that break down enkephalins, endogenous opioid peptides that regulate mood and stress. This could potentially lead to increased enkephalin levels, enhancing their anxiolytic effects.
2. Research and Clinical Studies 🔬
Neurocognitive and Mental Health
Anxiety: In a study comparing Selank to a generic benzodiazepine, Selank's effects on anxiety levels appeared similar, and it seemed to reverse the reduction of enkephalin levels observed in the anxiety models.
Memory and Learning: Studies on murine models suggested that Selank may improve learning abilities by reducing errors and increasing correct solutions in a conditioned avoidance response (CAR) task.
Withdrawal Symptoms: In murine models with alcohol withdrawal symptoms, Selank appeared to reduce the symptoms after 48 hours, as measured by social interaction and maze tests.
Other Research Areas
Immunomodulation: A study on patients with Generalized Anxiety Disorder (GAD) and neurasthenia showed that Selank may change the ratio of Th1 and Th2 cytokines, which are regulators of the immune system.
Metabolic Effects: In murine models on a high-fat diet, Selank appeared to reduce weight gain and decrease levels of cholesterol and triglycerides.
Cardiovascular System: A study on feline models suggested that Selank might decrease arterial blood pressure and increase cerebral blood flow without affecting heart rate or the respiratory system.
3. Product Information 🧬
Molecular Formula: C33H57N11O9
Molecular Weight: 751.88 g/mol
Other Known Titles: TP-7, Selanc
Important Notice: Selank peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.