SNAP-8 (200mg)

SNAP-8 (Synaptosomal-associated protein 8) is a synthetic octapeptide that is being investigated for its potential to reduce the appearance of wrinkles and expression lines. It is an analog of the N-terminal end of the SNAP-25 protein and is hypothesized to work by destabilizing the SNARE complex, which is involved in neurotransmitter release.

Product Information

Export to Sheets

Pricing

Export to Sheets

Chemical Makeup

Export to Sheets

Research and Clinical Studies

Skin Wrinkling & Topography

SNAP-8 is being researched for its potential anti-wrinkling effects by competing with the SNAP-25 protein to bind with vesicle-associated membrane proteins. This action is thought to destabilize the SNARE complex, which may reduce the release of acetylcholine, a neurotransmitter that stimulates muscle contractions. The reduction in muscle activity is hypothesized to decrease the depth of wrinkles (1).

A clinical trial from 2021 reported that the peptide appeared to cause a notable reduction in lines within 15 minutes of exposure and a significant improvement in skin after 12 weeks (3). Another study suggested a 30% reduction in wrinkle depth after one month of use (5). SNAP-8 has also been reported to reduce the release of glutamate amino acid by almost 43% and may reduce wrinkles by an average of 35% (7).

SNARE Protein Complex

SNAP-8's potential to modulate the SNARE complex is a key focus of research. The SNARE complex is essential for the fusion of vesicles with the cell membrane, a process that releases neurotransmitters. By interfering with the formation of this complex, SNAP-8 may reduce the muscle contractions that cause expression lines. Researchers have suggested that the peptide's action potentially mimics that of botulinum neurotoxins, which are known to have a similar effect (6).

Disclaimer: SNAP-8 peptide is available for research and laboratory purposes only.