SS-31 (50mg)
$185.00 $160.00
SS-31 Product Information
Our SS-31 is a high-purity, synthetic peptide available in a 50mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-SS-31-50.
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SS-31, also known as MTP-131, is a synthetic tetrapeptide being researched for its potential to address mitochondrial dysfunction and oxidative stress. Its unique cationic charge allows it to easily permeate cell membranes and accumulate in the inner mitochondrial membrane, where it is thought to bind to cardiolipin, a key phospholipid.
1. Mechanisms of Action 🧪
SS-31's potential actions are primarily focused on the mitochondria, the powerhouse of the cell:
Mitochondrial Accumulation: The peptide's cationic charge allows it to accumulate in the inner mitochondrial membrane at concentrations that are over 1000 times greater than in the plasma.
Cardiolipin Interaction: Once inside, SS-31 is believed to bind to cardiolipin, an anionic phospholipid essential for efficient oxidative phosphorylation and ATP production.
Reducing Oxidative Stress: This binding is thought to disrupt the interaction between cardiolipin and cytochrome C, which reduces the oxidative damage to cardiolipin. This may lead to a decrease in the leakage of reactive oxygen species (ROS) and a restoration of mitochondrial function.
Preserving Mitochondrial Structure: By preserving the integrity of cardiolipin and the cristae membranes, SS-31 may help prevent mitochondrial swelling and improve overall mitochondrial health.
2. Research and Clinical Studies 🔬
Oxidative Stress and Aging
Retinopathy: In a murine model of diabetic retinopathy, SS-31 appeared to improve retinal cell structures and reduce the permeability of the inner blood retinal barrier. It also appeared to diminish markers of oxidative stress while enhancing proteins that protect against cell death.
Cardiac Aging: A study on aged murine models suggested that SS-31 may reverse age-associated proteomic oxidation in the heart, particularly in proteins crucial for mitochondrial and cardiac function.
Sarcopenia: In aged murine models, SS-31 exposure appeared to counteract the age-related decrease in mitochondrial ATP production and enhanced the efficiency of oxidative phosphorylation.
Neuroprotection and Metabolic Conditions
Neuronal Injury: In murine models with neuronal injury, SS-31 appeared to counteract mitochondrial impairment and lessen secondary neuronal injury. It was suggested to reduce ROS content and mitigate neurological impairments.
Metabolic Disorders: In models of type 2 diabetes, SS-31 appeared to mitigate elevated levels of ROS and reduce endoplasmic reticulum (ER) stress, suggesting a protective effect on leukocytes.
Kidney Function: Studies on murine models with acute kidney injury showed that SS-31 appeared to protect the mitochondrial cristae membranes during ischemia, leading to a swift recovery of ATP and a reduction in tissue damage.
3. Product Information 🧬
Molecular Formula: C32H49N9O5
Molecular Weight: 639.8 g/mol
Other Known Titles: MTP-131, Szeto-Schiller-31
Important Notice: SS-31 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.