Syn-AKE (200mg)

Syn-AKE, also known as Tripeptide-3, is a synthetic peptide designed to mimic the muscle-relaxing effects of Waglerin-1, a component of Temple Viper venom. It is being investigated for its potential to reduce the appearance of wrinkles and expression lines by temporarily inhibiting muscle contractions.

Product Information

Pricing

Chemical Makeup

Research and Clinical Studies

Mechanism of Action & Wrinkle Reduction

Syn-AKE is being researched for its potential to act as a reversible antagonist of the nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. By binding to these receptors, it is thought to prevent the release of acetylcholine, a neurotransmitter that signals muscle contractions. This temporary inhibition of muscle activity is hypothesized to reduce the depth of wrinkles, particularly expression lines (2).

In one study, the peptide reportedly reduced the frequency of muscle cell contractions by 82% after two hours of exposure (4). Clinical trials have also shown promising results, with one study reporting a reduction of up to 52% in the appearance of wrinkle size in test volunteers after 28 days of a 4% formulation applied twice daily (10, 11). Another three-month study reported significant improvements in wrinkles shortly after exposure and at 1 and 3 months (9).

Potential Safety & Permeability

Unlike Waglerin-1, which can affect GABA receptors in the brain, initial research suggests that Syn-AKE does not have this effect, potentially lacking the risks associated with the viper venom component. The antagonism of Syn-AKE on nAChRs is believed to be reversible, which suggests its effects on muscle contractions are temporary and can be reversed when the peptide is no longer present (5, 6).

Disclaimer: Syn-AKE peptide is available for research and laboratory purposes only.