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Thyrotropin Product Information
Our Thyrotropin is a high-purity, synthetic peptide available in a 25mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-THYROTRP-25.
Pricing and Discounts
5-8 units: A 5% discount is applied, with a price of $69.35 per unit.
9+ units: A 10% discount is applied, with a price of $65.70 per unit.
We also offer FREE shipping on all orders over $200.
Thyrotropin, also known as Protirelin, is a synthetic tripeptide that is an analog of the naturally occurring thyrotropin-releasing hormone (TRH). It is being researched for its potential to stimulate the pituitary gland to release thyroid-stimulating hormone (TSH). Thyrotropin is also being investigated for its possible effects on the central nervous system (CNS), including its potential role as a neuromodulator.
1. Mechanisms of Action 🧪
Thyrotropin's potential actions are primarily focused on the endocrine and central nervous systems:
Pituitary Gland Stimulation: Thyrotropin is thought to bind to TRH receptors (TRH-1 and TRH-2) in the pituitary gland. This interaction may trigger a signaling cascade involving an increase in intracellular calcium, which leads to the synthesis and release of TSH. TSH, in turn, acts on the thyroid gland to regulate the production of thyroid hormones (T3 and T4).
Neuromodulatory Effects: In the CNS, Thyrotropin is being researched for its potential to modulate neurotransmitter systems. Studies suggest it may inhibit the release of excitatory neurotransmitters like glutamate and aspartate during heightened neuronal activity.
Behavioral Regulation: The peptide may affect neurotransmitter pathways involving serotonin and dopamine, which are key in regulating mood. Its effects on behavior are thought to be temporary and dependent on the individual's existing neural state.
2. Research and Clinical Studies 🔬
Central Nervous System: Studies have shown that Thyrotropin may inhibit the release of excitatory neurotransmitters in the hippocampus during neuronal activation, suggesting a role in controlling neural excitability.
Amyotrophic Lateral Sclerosis (ALS): Researchers are considering Thyrotropin's potential as a neuromodulator that may help mitigate the symptoms of ALS, particularly during periods of hypothalamic nervous system hyperactivity.
Behavioral Research: In a clinical study on subjects with depressive symptoms, Thyrotropin appeared to be associated with a significant reduction in depressive behavior in some individuals when administered intrathecally.
Cardiovascular Effects: Clinical and preclinical studies have suggested that Thyrotropin may contribute to an elevation in blood pressure and heart rate. Research indicates that this may be a localized action mediated by various autonomic nervous system regulations in specific areas of the hypothalamus.
3. Product Information 🧬
Molecular Formula: C16H22N6O4
Molecular Weight: 362.39 g/mol
Other Known Titles: Protirelin
Important Notice: Thyrotropin peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.