Tripeptide-29 (200mg)
$185.00 $176.00
Tripeptide-29 Product Information
Our Tripeptide-29 is a high-purity, synthetic peptide available in a 200mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-Tripeptide-29.
Pricing and Discounts
5-8 units: A 5% discount is applied, with a price of $167.20 per unit.
9+ units: A 10% discount is applied, with a price of $158.40 per unit.
We also offer FREE shipping on all orders over $200.
Tripeptide-29 (Glycylprolylhydroxyproline) is a small, naturally occurring peptide that is a primary building block of collagen protein. It is being researched for its potential to stimulate collagen synthesis and maintain the integrity of collagen fibers. Beyond its role in collagen, Tripeptide-29 may also have potential as an antioxidant, anti-inflammatory, and antidiabetic agent, and may influence platelet aggregation.
1. Mechanisms of Action 🧪
Tripeptide-29's potential actions are diverse, reflecting its role as a fundamental component of collagen:
Collagen Synthesis and Stability: The peptide is believed to be a major contributor to the stability of Type 1 collagen molecules. Studies suggest that its structure may enhance collagen stability, reduce UV-related damage, and prevent degradation. It is thought to work by reducing advanced glycation end products (AGEs) and inhibiting matrix metalloproteinases (MMPs), which break down the skin matrix.
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Dipeptidyl Peptidase-IV (DPP-IV) Inhibition: Tripeptide-29 may act as a competitive inhibitor of the enzyme DPP-IV. By inhibiting DPP-IV, it may prevent the rapid inactivation of hormones like GLP-1 and GIP, which are involved in regulating glucose and energy metabolism. This could potentially lead to increased insulin secretion and lower blood glucose levels.
Platelet Aggregation: The peptide may play a role in blood clotting. Research suggests that it can stimulate the glycoprotein VI (GPVI) receptor on platelets, leading to tyrosine phosphorylation of key signaling molecules. This action may ultimately trigger platelet aggregation, a crucial step in forming a blood clot to prevent bleeding.
2. Research and Clinical Studies 🔬
Collagen and Skin Health
Cellular Aging: An in vitro study on dermal fibroblasts suggested that Tripeptide-29 might mitigate cellular aging by inhibiting glycation and oxidative stress.
Oxidative Stress: The peptide was associated with a reduction in reactive oxygen species (ROS) and a lower build-up of AGEs, which are factors that accelerate skin cell aging.
Metabolic and Hematological Effects
Glucose Control: Studies have identified Tripeptide-29 as a potential inhibitor of DPP-IV, an enzyme that inactivates glucose-regulating hormones.
Blood Clotting: Researchers suggest that Tripeptide-29 is a sufficient motif to activate the platelet collagen receptor GPVI, which may stimulate the formation of thrombi to prevent excessive bleeding.
3. Product Information 🧬
Molecular Formula: C12H19N3O5
Molecular Weight: 285.3 g/mol
Other Known Titles: Glycylprolylhydroxyproline
Important Notice: Tripeptide-29 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.