VIP (6mg)
$75.00 $64.00
VIP Product Information
Our VIP is a high-purity, synthetic peptide available in a 6mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-VIP-6.
Pricing and Discounts
5-8 units: A 5% discount is applied, with a price of $60.80 per unit.
9+ units: A 10% discount is applied, with a price of $57.60 per unit.
We also offer FREE shipping on all orders over $200.
Vasoactive Intestinal Peptide (VIP) is a naturally occurring peptide hormone that is being researched for its potential pleiotropic actions as a neurotransmitter, vasodilator, and immune regulator. VIP is composed of 28 amino acid residues and is found in both the central and peripheral nervous systems. Researchers speculate that its wide distribution and ability to bind to multiple G protein-coupled receptors (VPAC1, VPAC2, and PAC1) may allow it to exert a broad range of biological effects.
1. Mechanisms of Action 🧪
VIP's potential actions are diverse and depend on the location of its receptors:
Receptor Binding: VIP binds to three main G protein-coupled receptors—VPAC1, VPAC2, and PAC1. This binding is thought to activate the adenylate cyclase pathway, leading to the production of cAMP, a key secondary messenger involved in various biological activities.
Anti-Inflammatory Effects: VIP is being researched for its potential to reduce inflammation. It may do this by inhibiting the synthesis of inflammatory cytokines and chemokines in both the innate and adaptive immune systems.
Vasodilation and Secretion: The name Vasoactive Intestinal Peptide suggests its potential to relax blood vessels (vasodilation) and stimulate secretion, particularly in the gastrointestinal tract.
2. Research and Clinical Studies 🔬
Inflammation: In murine models of necrotizing enterocolitis (NEC), exogenous VIP appeared to reduce the severity of the condition, decrease proinflammatory cytokine levels, and help preserve the integrity of the intestinal barrier.
Blood-Brain Barrier (BBB): VIP is being researched for its neuroprotective potential and its possible role in maintaining the integrity of the BBB and blood-spinal barrier (BSB). Autoimmune responses targeting VIP receptors may compromise these barriers, leading to neuroinflammation.
Cardiac Fibrosis: VIP has been associated with a potential reduction in cardiac fibrosis. In murine models, VIP appeared to downregulate key components of the renin-angiotensin system, a pathway implicated in fibrotic processes.
Behavioral Responses: VIP neurons in the hypothalamus have been linked to behavioral responses. VIP may influence the secretion of prolactin, a hormone associated with behaviors like affiliation and aggression. It is also being studied for its role in regulating circadian rhythms and social behavior networks.
3. Product Information 🧬
Molecular Formula: C147H237N43O43S
Molecular Weight: 3326.8 g/mol
Other Known Titles: PHM27, Vasoactive intestinal polypeptide
Important Notice: VIP peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.